Filter Cartridges: your automation friendly alternative to Syringe Filters

Sample filtration is highly recommended in HPLC analysis in order to achieve the best analytical results. In this post we will evaluate a new filtration strategy that can be executed just before injection in LC/LC-MS systems.

The elimination of solid materials by sample filtration represents a crucial phase of HPLC analysis, as the presence of sample particulates can interfere with the compound of interest and very easily clog up the separation column. These events can have a bad impact on the separation performance and often provoke the necessity to replace the column - with the resulting downtime and costs - or the loss of precious samples or other relevant issues. For these reasons, in order to achieve the best analysis result in a time- and cost-saving way, sample filtration is usually carried out as last preparation step before sample injection.

Varieties of filter devices are available in the market for sample filtration before HPLC analysis. The filter cartridge represents an alternative to the more common syringe filter, that is attractive as more automation friendly. In fact, this kind of support brings all of the benefits of filtration to the standard SPE cartridge format.

Filter types of filter cartridges correspond to the respective syringe filters in terms of membrane types and pore sizes, but the filter cartridges are more easily handled by automation devices.

The automation of sample filtration allows to optimize the filtration efficiency. In fact, automation allows the production of injection-ready filtrates in few minutes, allowing to perform the filtration online and just before the sample injection. Online filtration, executed at a fixed time before the injection, is particularly important for clarifying highly particle-laden samples that are prone to quickly re-form particulates.

Discover the solution proposed by HTA to automate the process of sample filtration by filter cartridges.

Request the Full flyer “Sample Filtration Automation by HT4000E” to learn more.