HTA Autosamplers for Preparative and Semi-Preparative HPLC systems

Do you have a preparative or semi-preparative HPLC system in your lab? Are you considering automating your purification workflow and exploring the solutions available on the market? Typically, you face two options.

The first is to use an analytical HPLC autosampler that has been adapted to handle larger injection volumes, which is what most manufacturers on the market offer. While this may seem like a convenient choice, these autosamplers are not designed for purification. They are optimized for sample loading in HPLC systems for qualitative or quantitative analysis, without specific focus on maximizing sample recovery. Choosing this route can lead to reduced sample recovery, sub-optimal analyte transfer, and final purification yields that fall below expectations—sometimes even worse than manual handling.

The second option is to select an autosampler specifically engineered for preparative and semi-preparative HPLC. HTA offers advanced solutions capable of handling large-volume injections up to 30ml while maintaining maximum sample recovery. These systems ensure nearly complete transfer of precious samples and achieve near-zero carryover, delivering reliable, high-performance results even in the most demanding workflows.

With HTA autosamplers, you can optimize the yields of your purification processes while ensuring precision, efficiency, and reliability. Among HTA’s offerings, you can select the solution that best fits your laboratory’s needs in terms of versatility and budget, giving you confidence that your purification process will perform at its best.

Request the Full Solution paper “Preparative and Semi-Preparative LC Autosamplers” to learn more.